Agent 47 will always start every mission carrying the Fiber Wire, unless changed during the planning stages. The weapon must be used from behind a target's back by using the garrote option.
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|Lethal Melee||Amputation Knife - Battle Axe - Circumcision Knife - Cleaver - Fiber Wire - Fire Axe - Folding Knife - Hatchet - Kitchen Knife - Letter Opener - Saber - Scissors - Screwdriver|
|Non-Lethal Melee||Baseball Bat - Bust - Crowbar - Expired Can of Spaghetti Sauce - Fire Extinguisher - Fire Poker - Golf Club - Hammer - Lead Pipe - Police Baton - Pool Ball - Shovel - Soda Can - Wrench|